原创力文档progress in spondylarthritis. mechanisms of new bone formation in spondyloarthritis脊椎关节炎的进展。.pdfVIP
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progress in spondylarthritis. mechanisms of new bone formation in spondyloarthritis脊椎关节炎的进展。
Available online /content/11/2/221
Review
Progress in spondylarthritis
Mechanisms of new bone formation in spondyloarthritis
Rik JU Lories, Frank P Luyten and Kurt de Vlam
Laboratory for Skeletal Development and Joint Disorders, Division of Rheumatology, Department of Musculoskeletal Sciences, Katholieke Universiteit
Leuven, Belgium
Corresponding author: Rik Lories, Rik.Lories@uz.kuleuven.be
Published: 27 April 2009 Arthritis Research Therapy 2009, 11:221 (doi:10.1186/ar2642)
This article is online at /content/11/2/221
© 2009 BioMed Central Ltd
Abstract into the bone through a fibrocartilaginous connection, is
Targeted therapies that neutralize tumour necrosis factor are often hypothesized to be the primary disease localization in SpA
able to control the signs and symptoms of spondyloarthritis. How- [4]. Entheses are found as a part of the joint organ or at extra-
ever, recent animal model data and clinical observations indicate articular sites [5,6]. The synovium and the underlying bone
that control of inflammation may not be sufficient to impede marrow are in close contact and communication with the
disease progression toward ankylosis in these patients. Bone entheses [5-7]. Although compelling evidence is lacking,
morphogenetic proteins and WNTs (wingless-type like) are likely to
synovitis and osteitis in SpA can be understood by this close
play an important role in ankylosis and could be therapeutic
targets. The relationship bet
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