原创力文档prognostic value of immunohistochemical surfactant protein a expression in regenerativehyperplastic alveolar epithelial cells in idiopathic interstitial pneumonias预后价值表达蛋白免疫组织化学表面活性剂的regenerativehyperplastic肺泡上皮细胞在特发性间质性肺炎.pdfVIP
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prognostic value of immunohistochemical surfactant protein a expression in regenerativehyperplastic alveolar epithelial cells in idiopathic interstitial pneumonias预后价值表达蛋白免疫组织化学表面活性剂的regenerativehyperplastic肺泡上皮细胞在特发性间质性肺炎
Nagata et al. Diagnostic Pathology 2011, 6:25
/content/6/1/25
RESEARCH Open Access
Prognostic value of immunohistochemical
surfactant protein A expression in regenerative/
hyperplastic alveolar epithelial cells in idiopathic
interstitial pneumonias
1* 2,3 1 4 5
Nobuhiko Nagata , Yasuhiko Kitasato , Kentaro Wakamatsu , Masaharu Kawabata , Kazuo Fukushima ,
Akira Kajiki1, Yoshinari Kitahara1 and Kentaro Watanabe6
Abstract
Background: It is difficult to predict survival in patients with idiopathic pulmonary fibrosis. Recently, several
proteins, such as surfactant protein (SP) and KL-6, have been reported to be useful biologic markers for prediction
of prognosis for interstitial pneumonias. It is not clear whether there is any relationship between expression of
these proteins in regenerative/hyperplastic alveolar epithelial cells and prognosis of idiopathic interstitial
pneumonias (IIPs).
Objectives: This study aimed to elucidate the clinical significance of the expression of such lung secretory proteins
as SP-A and KL-6 in lung tissues of patients with IIPs.
Methods: We retrospectively investigated the immunohistochemical expression of SP-A, KL-6, cytokeratin (CK), and
epithelial membrane antigen (EMA) in alveolar epithelial cells in lung tissues obtained from surgical lung biopsy in
43 patients with IIPs, and analyzed the correlation between expression of these markers and the prognosis of each
IIP patient. CK and EMA were used as general markers for epithelial cells.
Results: In patients with usual interstitial pneumonia (UIP), the ratio of SP-A positive epithelial cells to all alveolar
epithelial cells (SP-A positive ratio) in the collapsed and mural fibrosis areas varied,
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