pulmonary epithelioid hemangioendothelioma accompanied by bilateral multiple calcified nodules in lung肺上皮样血管内皮瘤伴随双边多个肺钙化结节.pdfVIP

Jinghong and Lirong Diagnostic Pathology 2011, 6:21 /content/6/1/21 CASE REPORT Open Access Pulmonary epithelioid hemangioendothelioma accompanied by bilateral multiple calcified nodules in lung * Xu Jinghong, Chen Lirong Abstract Pulmonary epithelioid hemangioendothelioma (PEH) is a rare vascular tumor. It can present either as one solitary nodule or bilateral multiple nodules, usually without calcification. We describe here an unusual case of PEH in a 42-year-old female with a 6.0 cm dominant mass along with bilateral multiple calcified small nodules measuring 0.2-1.0 cm in diameter with a 25-year plus followup history. Overall histologic findings of the solitary tumor accorded with conventional PEH. While multiple calcified small nodules were composed predominantly of intra- alveolar homogeneously eosinophilic matrix, and only a few bland small cells were embedded in it. This lesion has never been reported in the literature. After comprehensive analysis of morphology, radiography, histochemistry, immunohistochemistry and differential diagnoses, PEH presenting multiple calcified small nodules was confirmed. Background number and size in the serial follow-up chest radiographs. Epithelioid hemangioendothelioma (formerly known as Twenty years later (May 2002), a follow-up X-ray film intravascular bronchioalveolar tumor, IVBAT) is an showed one approximately 3.0 cm sized, well-defined uncommon tumor of vascular endothelial origin, with mass in the middle field of right lung. Because of the an intermediate course between hemangioma and con- absence of symptoms, she had always rejected any medical ventional angiosarcoma [1-3]. PEH typically occurs