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recent advances in cyclonucleosides c-cyclonucleosides and spore photoproducts in damaged dna最近的进步cyclonucleosides c-cyclonucleosides和孢子photoproducts受损的dna.pdf

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recent advances in cyclonucleosides c-cyclonucleosides and spore photoproducts in damaged dna最近的进步cyclonucleosides c-cyclonucleosides和孢子photoproducts受损的dna

Molecules 2012, 17, 11630-11654; doi:10.3390/molecules171011630 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Review Recent Advances in Cyclonucleosides: C-Cyclonucleosides and Spore Photoproducts in Damaged DNA Yuichi Yoshimura * and Hiroki Takahata Faculty of Pharmaceutical Sciences, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan; E-Mail: takahata@tohoku-pharm.ac.jp * Author to whom correspondence should be addressed; E-Mail: yoshimura@tohoku-pharm.ac.jp; Tel.: +81-22-727-0145; Fax: +81-22-275-2013. Received: 30 August 2012; in revised form: 25 September 2012 / Accepted: 26 September 2012 / Published: 28 September 2012 Abstract: Cyclonucleosides which are fixed in a specific conformation around the glycosyl bond by a carbon and heteroatom chain constitute a unique category of nucleoside derivatives. Because they are structural analogs, cyclonucleosides and oligodeoxynucleotides containing them would be useful tools for investigating the biological functions and conformations of DNA, RNA as well as their steric interactions with proteins. C-Cyclonucleosides bridged by a carbon chain between the base and sugar moieties are the most attractive from the synthetic points of view as well as for use as biological tools. In this review, recent progress of the synthesis of C-cyclonucleosides is surveyed. Among the C-cyclonucleosides, 5′,8-C-cyclodeoxyadenosine is one of the well-known derivatives