原创力文档relationship between patient-reported disease severity in osteoarthritis and self-reported pain, function and work productivity在骨关节炎patient-reported疾病严重程度之间的关系和自我报告的疼痛,功能和工作效率.pdfVIP
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relationship between patient-reported disease severity in osteoarthritis and self-reported pain, function and work productivity在骨关节炎patient-reported疾病严重程度之间的关系和自我报告的疼痛,功能和工作效率
Sadosky et al. Arthritis Research Therapy 2010, 12:R162
/content/12/4/R162
RESEARCH ARTICLE Open Access
Relationship between patient-reported disease
severity in osteoarthritis and self-reported pain,
function and work productivity
1* 2 2 3
Alesia B Sadosky , Andrew G Bushmakin , Joseph C Cappelleri , David R Lionberger
Abstract
Introduction: Understanding the relationship between patient-reported osteoarthritis (OA) severity and other
patient-reported outcomes in the real-world clinical setting can provide a basis for appropriate patient
management. The objective of this study was to determine how patient-reported OA severity correlates with
patient-reported outcomes including pain, function and productivity.
Methods: We used the Adelphi Disease Specific Programme (DSP) for OA, a database aggregated from large,
multinational, observational studies for specific chronic diseases. Data were obtained based on a 0 to 100 mm pain
visual analogue scale (VAS) and a series of questions including functioning (that is, activities of daily living) and
work productivity. OA severity was rated by the patients based on the question “How bad would you say your
arthritis is now?” with potential responses of “mild,” “moderate,” and “severe.” Regression models and chi-square
analyses were used to evaluate the relationships between self-reported OA severity and other outcomes.
Results: Of 998 subjects in the OA DSP U.S. database, 714 (72.5%) agreed to participate. This sample was
predominantly female (61.7%) with a mean age of 63.8 ± 12.9 years. Increased OA severity was associated with an
older population (P 0.05). With increasing OA severity (mild, moderate, severe), statistically significant differences
(P 0.05) were obs
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