relationship between obesity, ethnicity and risk of late stillbirth a case control study肥胖之间的关系,种族和后期死产的风险一个病例对照研究.pdfVIP

Stacey et al. BMC Pregnancy and Childbirth 2011, 11:3 /1471-2393/11/3 RESEARCH ARTICLE Open Access Relationship between obesity, ethnicity and risk of late stillbirth: a case control study 1,2* 3 3 1 4 Tomasina Stacey , John MD Thompson , Edwin A Mitchell , Alec J Ekeroma , Jane M Zuccollo , Lesley ME McCowan1 Abstract Background: In high income countries there has been little improvement in stillbirth rates over the past two decades. Previous studies have indicated an ethnic disparity in the rate of stillbirths. This study aimed to determine whether maternal ethnicity is independently associated with late stillbirth in New Zealand. Methods: Cases were women with a singleton, late stillbirth (≥28 weeks’ gestation) without congenital abnormality, born between July 2006 and June 2009 in Auckland, New Zealand. Two controls with ongoing pregnancies were randomly selected at the same gestation at which the stillbirth occurred. Women were interviewed in the first few weeks following stillbirth, or at the equivalent gestation for controls. Detailed demographic data were recorded. The study was powered to detect an odds ratio of 2, with a power of 80% at the 5% level of significance, given a prevalence of the risk factor of 20%. A multivariable regression model was developed which adjusted for known risk factors for stillbirth, as well as significant risk factors identified in the current study, and adjusted odds ratios and 95% confidence intervals were calculated. Results: 155/215 (72%) cases and 310/429 (72%) controls consented. Pacific ethnicity, overweight and obesity, grandmultiparity, not being married, not being in paid work, social deprivation, exposure to tobacco smoke and use of recreational