原创力文档reduced antioxidant defense in early onset first-episode psychosis a case-control study降低抗氧化防御早发性首发精神病病例对照研究.pdfVIP
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reduced antioxidant defense in early onset first-episode psychosis a case-control study降低抗氧化防御早发性首发精神病病例对照研究
Micó et al. BMC Psychiatry 2011, 11:26
/1471-244X/11/26
RESEARCH ARTICLE Open Access
Reduced antioxidant defense in early onset
first-episode psychosis: a case-control study
1 1 1 2 2
Juan Antonio Micó , Maria Olga Rojas-Corrales , Juan Gibert-Rahola , Mara Parellada , Dolores Moreno ,
3 4 5 5 6 7
David Fraguas , Montserrat Graell , Javier Gil , Jon Irazusta , Josefina Castro-Fornieles , Cesar Soutullo ,
2 8 9 6 9
Celso Arango , Soraya Otero , Ana Navarro , Inmaculada Baeza , Mónica Martínez-Cengotitabengoa ,
Ana González-Pinto10*
Abstract
Background: Our objective is to determine the activity of the antioxidant defense system at admission in patients
with early onset first psychotic episodes compared with a control group.
Methods: Total antioxidant status (TAS) and lipid peroxidation (LOOH) were determined in plasma. Enzyme
activities and total glutathione levels were determined in erythrocytes in 102 children and adolescents with a first
psychotic episode and 98 healthy controls.
Results: A decrease in antioxidant defense was found in patients, measured as decreased TAS and glutathione
levels. Lipid damage (LOOH) and glutathione peroxidase activity was higher in patients than controls. Our study
shows a decrease in the antioxidant defense system in early onset first episode psychotic patients.
Conclusions: Glutathione deficit seems to be implicated in psychosis, and may be an important indirect biomarker
of oxidative stress in early-onset schizophrenia. Oxidative damage
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