原创力文档reduced expression of microrna-100 confers unfavorable prognosis in patients with bladder cancer减少微rna - 100的表达带来不利的膀胱癌患者的预后.pdfVIP
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reduced expression of microrna-100 confers unfavorable prognosis in patients with bladder cancer减少微rna - 100的表达带来不利的膀胱癌患者的预后
Wang et al. Diagnostic Pathology 2012, 7:159
/content/7/1/159
RESEARCH Open Access
Reduced expression of microRNA-100 confers
unfavorable prognosis in patients with bladder
cancer
1 1 2 3 1 1 1
Sheng Wang , Sheng Xue , Yuanqing Dai , Jianfu Yang , Zhijun Chen , Xiwu Fang , Wensheng Zhou ,
Wei Wu2 and Qingwen Li1*
Abstract
Objective: MicroRNA-100 (miR-100) has been demonstrated to be downregulated in bladder cancer tissues, and
enforced expression of this miRNA may inhibit cell growth and colony formation of human bladder cancer 5637
cells in vitro. However, the clinical significance of miR-100 in human bladder cancer has not yet been elucidated.
Thus, the aim of this study was to investigate the diagnostic and prognostic values of miR-100 in this disease.
Methods: Expression levels of miR-100 in 126 pairs of bladder cancer and adjacent normal tissues were detected
by TaqMan real-time quantitative RT-PCR assay. In order to determine its prognostic value, overall survival (OS) and
progression-free survival (PFS) were evaluated using the Kaplan-Meier method, and multivariate analysis was
performed using the Cox proportional hazard analysis.
Results: Expression levels of miR-100 in bladder cancer tissues were significantly lower than those in adjacent
normal tissues (mean expression level: 2.6 ± 1.2 vs. 3.9 ± 1.5, P 0.001). When categorized into low vs. high
expression, low miR-100 expression was negatively associated with the stage (P = 0.01), the recurrence (P = 0.008),
the progression (P = 0.01), and the death (P 0.001) of patients with bladder cancer. Moreover, low miR-100
expression clearly predicted poorer PFS (P = 0.001) and OS (P 0.001). In the multivariate analysis, low miR-100
expres
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