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remifentanil discontinuation and subsequent intensive care unit-acquired infection a cohort studyremifentanil中止和随后的重症监护unit-acquired感染一个队列研究.pdf

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remifentanil discontinuation and subsequent intensive care unit-acquired infection a cohort studyremifentanil中止和随后的重症监护unit-acquired感染一个队列研究

Available online /content/13/2/R60 Vol 13 No 2 Open Access Research Remifentanil discontinuation and subsequent intensive care unit-acquired infection: a cohort study 1,2 1 1 1 2 Saad Nseir , Jérémy Hoel , Guillaume Grailles , Aude Soury-Lavergne , Christophe Di Pompeo , Daniel Mathieu1 and Alain Durocher1,2 1Intensive Care Unit, Calmette Hospital, University Hospital of Lille, boulevard du Pr Leclercq, 59037 Lille cedex, France 2Medical Assessment Laboratory, Lille II University, 1 place de Verdun, 59045 Lille, France Corresponding author: Saad Nseir, s-nseir@chru-lille.fr Received: 12 Dec 2008 Revisions requested: 30 Jan 2009 Revisions received: 4 Mar 2009 Accepted: 21 Apr 2009 Published: 21 Apr 2009 Critical Care 2009, 13:R60 (doi:10.1186/cc7788) This article is online at: /content/13/2/R60 © 2009 Nseir et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Recent animal studies demonstrated Incidence rate of ICU-acquired infection was 38 per 1000 ICU- immunosuppressive effects of opioid withdrawal resulting in a days. Ventilator-associated pneumonia was the most frequently higher risk of infection. The aim of this study was to determine diagnosed ICU-acquired infection (23% of study patients). the impact of remifentanil discontinuation on intensive care unit Pseudomonas aeruginosa was the most frequ