原创力文档regioselective suzuki-miyaura reaction application to the microwave-promoted synthesis of 4,7-diarylquinazolines特定选择的suzuki-miyaura microwave-promoted合成的反应应用4,7-diarylquinazolines.pdfVIP
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regioselective suzuki-miyaura reaction application to the microwave-promoted synthesis of 4,7-diarylquinazolines特定选择的suzuki-miyaura microwave-promoted合成的反应应用4,7-diarylquinazolines
Molecules 2010, 15, 2949-2961; doi:10.3390/molecule
OPEN ACCESS
molecules
ISSN 1420-3049
/journal/molecules
Article
Regioselective Suzuki-Miyaura Reaction: Application to the
Microwave-promoted Synthesis of 4,7-Diarylquinazolines
Youssef Kabri, Pierre Verhaeghe, Armand Gellis and Patrice Vanelle *
Laboratoire de Pharmacochimie Radicalaire, Faculté de Pharmacie, Universités d’Aix-Marseille I, II et
III - UMR CNRS 6264 , Laboratoire Chimie Provence, 27 Boulevard Jean Moulin, 13385 Marseille
cedex 05, France; E-Mails: youssef.kabri@univmed.fr (Y.K.); pierre.verhaeghe@univmed.fr (P.V.);
armand.gellis@univmed.fr (A.G.)
* Author to whom correspondence should be addressed; E-Mail: patrice.vanelle@univmed.fr;
Tel.: +33 491 835 580; Fax: +33 491 794 677.
Received: 24 March 2010; in revised form: 8 April 2010 / Accepted: 21 April 2010 /
Published: 27 April 2010
Abstract: New diarylquinazolines displaying pharmaceutical potential were synthesized in
high yields from 4,7-dichloro-2-(2-methylprop-1-enyl)-6-nitroquinazoline by using
microwave-promoted regioselective Suzuki-Miyaura cross-coupling reactions.
Keywords: quinazoline; Suzuki-Miyaura reaction; microwaves; SRN 1
Introduction
In 1979, Suzuki and Miyaura introduced organoboron reagents into the realm of cross-coupling
chemistry, by demonstrating a palladium-catalyzed reaction of 1-alkenylboranes with aryl and alkynyl
halides [1,2]. Since its discovery, this reaction, which is now referred to as the Suzuki-Miyaura
reaction, has seen signi
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