real-time translocation and function of pkcβii isoform in response to nociceptive signaling via the trpv1 pain receptor实时易位和功能pkcβii同种型应对疼痛的信号通过trpv1受体疼痛.pdfVIP

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real-time translocation and function of pkcβii isoform in response to nociceptive signaling via the trpv1 pain receptor实时易位和功能pkcβii同种型应对疼痛的信号通过trpv1受体疼痛.pdf

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real-time translocation and function of pkcβii isoform in response to nociceptive signaling via the trpv1 pain receptor实时易位和功能pkcβii同种型应对疼痛的信号通过trpv1受体疼痛

Pharmaceuticals 2011, 4, 1503-1517; doi:10.3390/ph4111503 OPEN ACCESS Pharmaceuticals ISSN 1424-8247 /journal/pharmaceuticals Article Real-Time Translocation and Function of PKCβII Isoform in Response to Nociceptive Signaling via the TRPV1 Pain Receptor Sravan Mandadi 1,3,*, Patricia J. Armati 2 and Basil D. Roufogalis 3,* 1 Hotchkiss Brain Institute, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N4N1, Canada 2 Brain Mind Research Institute and the Nerve Research Foundation, University of Sydney, Sydney, NSW 2006, Australia 3 Faculty of Pharmacy, University of Sydney, Room 341, Pharmacy and Bank Building A15, Sydney, NSW 2006, Australia * Authors to whom correspondence should be addressed; E-Mails: smandadi@ucalgary.ca (S.M.); basil.roufogalis@.au (B.D.R.); Tel.: +1-403-220-8427 (S.M.); +61-2-9351-3391 (B.D.R.); Fax: +1-403-283-2700 (S.M.); +61-2-9351-4391 (B.D.R.). Received: 12 October 2011; in revised form: 26 October 2011 / Accepted: 7 November 2011 / Published: 11 November 2011 Abstract: Serine/threonine protein kinase C βII isoform (PKCβII) or the pain receptor transient receptor potential vanilloid 1 (TRPV1) have been separately implicated in mediating heat hyperalgesia during inflammation or diabetic neuropathy. However, detailed information on the role of PKC βII in nociceptive signaling mediated by TRPV1 is lacking. This study presents evidence for activation and translocation of the PKC βII isoform as a signaling event in nociception medi