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pyranoxanthones from mesua ferrea从mesua pyranoxanthones ferrea
Molecules 2011, 16, 5647-5654; doi:10.3390/molecule
OPEN ACCESS
molecules
ISSN 1420-3049
/journal/molecules
Article
Pyranoxanthones from Mesua ferrea
Soek Sin Teh 1, Gwendoline Cheng Lian Ee 1,*, Mawardi Rahmani 1, Yun Hin Taufiq-Yap 1,
2 1
Rusea Go and Siau Hui Mah
1 Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 Serdang,
Selangor, Malaysia
2 Department of Biology, Faculty of Science, Universiti Putra Malaysia, 43400 Serdang,
Selangor, Malaysia
* Author to whom correspondence should be addressed; E-Mail: gwen@.my;
Tel.: +603-8946-6785.
Received: 1 April 2011 / Accepted: 10 June 2011 / Published: 30 June 2011
Abstract: Our phytochemical studies on the root bark extracts of Mesua ferrea have led to
the isolation of two new pyranoxanthones, mesuaferrin A (1) and mesuaferrin B (2). Five
other compounds – caloxanthone C (3), 1,8-dihydro-3-methoxy-6-methylanthraquinone
(4), β-sitosterol (5), friedelin (6) and betulinic acid (7) – were also successfully isolated.
Structural elucidations of these compounds were achieved using 1D and 2D NMR and MS
techniques.
Keywords: mesuaferrin A; mesuaferrin B; pyranoxanthone; Mesua ferrea ; Guttiferae
1. Introduction
Mesua ferrea (Clusiaceae) is a large evergreen tree, usually found growing in evergreen tropical to
semi-tropical forests. It is used in folk medicine for the treatment of fevers, dyspepsis and renal
diseases [1]. Some phytochemical invest
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