progress in osteoporosis and fracture prevention focus on postmenopausal women骨质疏松症和骨折预防进展集中在绝经后妇女.pdfVIP

Available online /content/11/5/251 Review Progress in osteoporosis and fracture prevention: focus on postmenopausal women Kenneth G Saag1 and Piet Geusens2 1Division of Clinical Immunology and Rheumatology, Center for Education and Research on Therapeutics, University of Alabama at Birmingham, 820 Faculty Office Tower, 510 20th Street South, Birmingham, AL 35294-3708, USA 2Department of Internal Medicine, Subdivision of Rheumatology, Maastricht University Medical Center, P. Debyelaan 25, Postbus 5800, 6202 AZ Maastricht, The Netherlands Biomedical Research Institute, University Hasselt, Agoralaan, gebouw D, B-3590 Diepenbeek, Belgium Corresponding author: Kenneth G Saag, ksaag@ Published: 14 October 2009 Arthritis Research Therapy 2009, 11:251 (doi:10.1186/ar2815) This article is online at /content/11/5/251 © 2009 BioMed Central Ltd Abstract evidence that the risk of first and subsequent fractures can be In the past decade, we have witnessed a revolution in osteo- prevented in daily clinical practice. porosis diagnosis and therapeutics. This includes enhanced understanding of basic bone biology, recognizing the severe The Fracture Risk Assessment Tool for consequences of fractures in terms of morbidity and short-term re- calculating the individual 10-year fracture risk fracture and mortality risk and case finding based on clinical risks, The clinical expression of osteoporosis is a fragility fracture, bone mineral density, new imaging approaches, and contributors but bone loss in and of itself is asymptomatic, which has led to secondary osteoporosis. Medic