progress in spondylarthritis. immunopathogenesis of spondyloarthritis which cells drive disease脊椎关节炎的进展。.pdfVIP

Available online /content/11/3/233 Review Progress in spondylarthritis Immunopathogenesis of spondyloarthritis: which cells drive disease? Lode Melis and Dirk Elewaut Department of Rheumatology, Ghent University Hospital, 0K12IB, De Pintelaan 185, 9000 Ghent, Belgium Corresponding author: Dirk Elewaut, dirk.elewaut@ugent.be Published: 25 June 2009 Arthritis Research Therapy 2009, 11:233 (doi:10.1186/ar2722) This article is online at /content/11/3/233 © 2009 BioMed Central Ltd Abstract the different disease phenotypes could consecutively mani- Spondyloarthritides, or SpA, form a cluster of chronic inflammatory fest in the same patient, (b) overlaps that make it impossible diseases with the axial skeleton as the most typical disease to distinguish between the different disorders are often seen, localisation, although extra-articular manifestations such as and (c) different disorders can affect different members of the intestinal inflammation may frequently occur during the course of same family. Apart from the presence of shared environmental the disease. This review summarises recent progress in our factors, this familial aggregation can be explained for the understanding of the immunopathogenesis of SpA with special most part by an important hereditary component in the emphasis on the cellular constituents considered to be responsible for the initiation and/or perpetuation of inflammation. There are pathogenesis of the disease. First-degree relatives of SpA s