原创力文档progression to microalbuminuria in patients with type 1 diabetes a seven-year prospective study在1型糖尿病患者微蛋白尿进展7年的前瞻性研究.pdfVIP
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progression to microalbuminuria in patients with type 1 diabetes a seven-year prospective study在1型糖尿病患者微蛋白尿进展7年的前瞻性研究
Cobas et al. Diabetology Metabolic Syndrome 2011, 3:21
DIABETOLOGY
/content/3/1/21
METABOLIC SYNDROME
RESEARCH Open Access
Progression to microalbuminuria in patients with
type 1 diabetes: a seven-year prospective study
1* 2 1 3 1
Roberta A Cobas , Bráulio Santos , Pedro CB da Silva , Ricardo Neves and Marilia B Gomes
Abstract
Background: The presence of microalbuminuria can be associated with overt nephropathy and cardiovascular
disease in patients with type 1 diabetes (T1D). We aimed to determine the incidence and evaluate the baseline
predictors for the development of microalbuminuria in patients with T1D.
Methods: This study is a longitudinal cohort study of 122 normoalbuminuric patients with T1D who were
receiving routine clinical care at baseline. A detailed medical history was taken, and a physical examination was
performed at baseline. All of the patients were regularly examined for diabetes-associated complications. An
analysis of predictors was performed using the Cox regression.
Results: Over 6.81 (3.59-9.75) years of follow-up, 50 (41%) of the patients developed microalbuminuria. The
incidence density was 6.79/100 people per year (95% CI 5.04-8.95), and the microalbuminuria developed after 5.9
(2.44-7.76) and 11 (5-15) years of follow-up and diabetes duration, respectively. After an individual Cox regression,
the baseline variables associated with the development of microalbuminuria were age, age at diagnosis, duration
of diabetes, systolic and diastolic blood pr
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