原创力文档progress in the use of rna interference as a therapy for chronic hepatitis b virus infection进步利用rna干扰治疗慢性乙型肝炎病毒感染.pdfVIP
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progress in the use of rna interference as a therapy for chronic hepatitis b virus infection进步利用rna干扰治疗慢性乙型肝炎病毒感染
Weinberg and Arbuthnot Genome Medicine 2010, 2:28
/content/2/4/28
RE VIE W
Progress in the use of RNA interference as a
therapy for chronic hepatitis B virus infection
Marc S Weinberg* and Patrick Arbuthnot
viral replication. Although nucleoside and nucleotide
Abstract
analogs are well tolerated, the emergence of viral resis-
Chronic infection with hepatitis B virus (HBV) occurs tance remains a problem [3]. Currently, the nucleoside/
in approximately 6% of the world’s population and nucleotide analogs lamivudine (3TC), adefovir, entecovir
carriers of the virus are at risk for hepatocellular and telbivudine are approved for use against HBV, with
carcinoma and cirrhosis. Current treatment regimens, lamivudine being the most widely used. However,
which include interferon-α and nucleoside/nucleotide prolonged lamivudine monotherapy is often associated
analogs, are only partially eective and new treatment with the emergence of viral resistance to the drug [4].
methods remain an important objective. Harnessing Although cross-resistance to other nucleoside/nucleotide
the RNA interference (RNAi) pathway to achieve analogs, such as entecavir, has been demonstrated, the
post-transcriptional silencing of rogue genetic preferred first line of therapy includes a combination of
elements is an exciting avenue for development of nucleoside/nucleotide analogs to limit the emergence of
novel therapeutic strategies. The specic and potent
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