pyrazinecarboxamides as potential elicitors of flavonolignan and flavonoid production in silybum marianum and ononis arvensis cultures in vitropyrazinecarboxamides flavonolignan和类黄酮生产的潜力等进行silybum marianum和ononis薄荷文化体外.pdfVIP

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pyrazinecarboxamides as potential elicitors of flavonolignan and flavonoid production in silybum marianum and ononis arvensis cultures in vitropyrazinecarboxamides flavonolignan和类黄酮生产的潜力等进行silybum marianum和ononis薄荷文化体外.pdf

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pyrazinecarboxamides as potential elicitors of flavonolignan and flavonoid production in silybum marianum and ononis arvensis cultures in vitropyrazinecarboxamides flavonolignan和类黄酮生产的潜力等进行silybum marianum和ononis薄荷文化体外

Molecules 2011, 16, 9142-9152; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Short Note Pyrazinecarboxamides as Potential Elicitors of Flavonolignan and Flavonoid Production in Silybum marianum and Ononis arvensis Cultures In Vitro Lenka Tumova 1,*, Jiri Tuma 2 and Martin Dolezal 3 1 Department of Pharmacognosy, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic 2 Department of Biology, Faculty of Science, University of Hradec Kralove, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic 3 Department of Pharmaceutical Chemistry and Pharmaceutical Analysis, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic * Author to whom correspondence should be addressed; E-Mail: tumova@faf.cuni.cz. Received: 29 September 2011; in revised form: 25 October 2011 / Accepted: 28 October 2011 / Published: 1 November 2011 Abstract: The effect of new synthetic pyrazinecarboxamide derivatives as potential elicitors of flavonolignan and flavonoid production in Silybum marianum and Ononis arvensis cultures in vitro was investigated. Both tested elicitors increased the production of flavonolignans in S. marianum callus and suspension cultures and flavonoids in O. arvensis callus and suspension cultures. Compound I, 5-(2-hydroxybenzoyl)- pyrazine-2-carboxamide, has shown to