pyrogallol structure in polyphenols is involved in apoptosis-induction on hek293t and k562 cells焦棓酸结构在多酚类物质参与apoptosis-induction hek293t和k562细胞.pdfVIP

Molecules 2008, 13, 2998-3006; DOI: 10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Pyrogallol Structure in Polyphenols is Involved in Apoptosis-induction on HEK293T and K562 Cells Shinya Mitsuhashi 1, Akiko Saito 2,3, Noriyuki Nakajima 4, Hiroshi Shima 5 and Makoto Ubukata 1,* 1 Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University, Kita-9, Nishi-9, Kita-ku, Sapporo 060-8589, Japan; E-mail: shinya@igm.hokudai.ac.jp (S. M.) 2 Biotechnology Center, Toyama Prefecture, Kosugi, Toyama 939-0398, Japan 3 Present address: Antibiotics Laboratory, Discovery Research Institute, RIKEN 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan; E-mail: saiaki@riken.jp (A. S.) 4 Biotechnology Research Center, Toyama Prefectural University, Kosugi, Toyama 939-0398, Japan; E-mail: nori@pu-toyama.ac.jp (N. N.) 5 Division of Cancer Chemotherapy, Research Institute, Miyagi Cancer Center, Natori, Japan; E- mail: shima-hi632@pref.miyagi.jp (H. S.) * Author to whom correspondence should be addressed; E-mail: m-ub@for.agr.hokudai.ac.jp; Tel. +81 11 706 3638, Fax: +81 11 706 3638. Received: 28 October 2008; in revised form: 27 November 2008 / Accepted: 3 December 2008 / Published: 4 December 2008 Abstract: As multiple mechanisms account for polyphenol-induced cytotoxicity, the development of structure-activity relationships (SARs) may facilitate research on cancer therapy. We studied SARs of representatives of 10 polyphenol