reanalysis of cancer mortality in japanese a-bomb survivors exposed to low doses of radiation bootstrap and simulation methods再分析日本原子弹幸存者的癌症死亡率暴露在低剂量的辐射引导和仿真方法.pdfVIP

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reanalysis of cancer mortality in japanese a-bomb survivors exposed to low doses of radiation bootstrap and simulation methods再分析日本原子弹幸存者的癌症死亡率暴露在低剂量的辐射引导和仿真方法.pdf

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reanalysis of cancer mortality in japanese a-bomb survivors exposed to low doses of radiation bootstrap and simulation methods再分析日本原子弹幸存者的癌症死亡率暴露在低剂量的辐射引导和仿真方法

Environmental Health BioMed Central Research Open Access Reanalysis of cancer mortality in Japanese A-bomb survivors exposed to low doses of radiation: bootstrap and simulation methods Greg Dropkin Address: Flat 5, 32 Sheil Road, Liverpool L6 3AE, UK E-mail: gregd@ Published: 9 December 2009 Received: 3 February 2009 Environmental Health 2009, 8:56 doi: 10.1186/1476-069X-8-56 Accepted: 9 December 2009 This article is available from: /content/8/1/56 © 2009 Dropkin; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The International Commission on Radiological Protection (ICRP) recommended annual occupational dose limit is 20 mSv. Cancer mortality in Japanese A-bomb survivors exposed to less than 20 mSv external radiation in 1945 was analysed previously, using a latency model with non-linear dose response. Questions were raised regarding statistical inference with this model. Methods: Cancers with over 100 deaths in the 0 - 20 mSv subcohort of the 1950-1990 Life Span Study are analysed with Poisson regression models incorporating latency, allowing linear and non- linear dose response. Bootstrap percentile and Bias-corrected accelerated (BCa) methods and simulation of the Likelihood Ratio Test lead to Confidence Intervals for Excess Relative Risk (ERR)