regioselective synthesis of 1-(2,6-dichloro-4-trifluoromethylphenyl)- 4-alkyl-1h-[1,2,3]-triazoles特定选择的合成1 -(2,6-dichloro-4-trifluoromethylphenyl)u2014u20144-alkyl-1h -氮杂四唑(1、2、3).pdfVIP

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regioselective synthesis of 1-(2,6-dichloro-4-trifluoromethylphenyl)- 4-alkyl-1h-[1,2,3]-triazoles特定选择的合成1 -(2,6-dichloro-4-trifluoromethylphenyl)u2014u20144-alkyl-1h -氮杂四唑(1、2、3).pdf

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regioselective synthesis of 1-(2,6-dichloro-4-trifluoromethylphenyl)- 4-alkyl-1h-[1,2,3]-triazoles特定选择的合成1 -(2,6-dichloro-4-trifluoromethylphenyl)u2014u20144-alkyl-1h -氮杂四唑(1、2、3)

Molecules 2008, 13, 556-566 molecules ISSN 1420-3049 © 2008 by MDPI /molecules Full Paper Regioselective Synthesis of 1-(2,6-Dichloro-4-Trifluoromethyl- phenyl)-4-Alkyl-1H-[1,2,3]-Triazoles 1,2,3 3,4,* 1, 3 3 Huanan Hu , Anjiang Zhang , Lisheng Ding *, Xinxiang Lei and Lixue Zhang 1 Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, P. R. China 2 Graduate School of Chinese Academy of Sciences, Beijing 100049, P. R. China 3 College of Chemistry and Material Engineering, Wenzhou University, Wenzhou 325027, P. R. China 4 Ningbo Institute of Material Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, P. R. China * Authors to whom correspondence should be addressed; E-mails: anjiangzhang@; lsding@; Tel: (+86) 574 Fax: (+86) 574 Received: 9 November 2007; in revised form: 13 February 2008 / Accepted: 20 February 2008/ Published: 3 March 2008 Abstract: A new and efficient method for the synthesis of 1-(2,6-dichloro-4-trifluoro- methylphenyl)-4-alkyl-1H-[1,2,3]-triazoles by the room temperature 1,3-dipolar cycloaddition of (2-azido-1,3-dichloro-5-trifluoromethyl)benzene with terminal alkynes in the presence of Cu (I) salt as catalyst is reported. All the reactions gave 1,4-disubstituted products with high regioselectivity, as no 1,5-disubstituted product was formed. The structures of all the title compounds have been