regional expression of hoxa4 along the aorta and its potential role in human abdominal aortic aneurysms区域的表达hoxa4沿主动脉在人类腹主动脉瘤及其潜在的作用.pdfVIP

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regional expression of hoxa4 along the aorta and its potential role in human abdominal aortic aneurysms区域的表达hoxa4沿主动脉在人类腹主动脉瘤及其潜在的作用.pdf

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regional expression of hoxa4 along the aorta and its potential role in human abdominal aortic aneurysms区域的表达hoxa4沿主动脉在人类腹主动脉瘤及其潜在的作用

Lillvis et al. BMC Physiology 2011, 11:9 /1472-6793/11/9 RESEARCH ARTICLE Open Access Regional expression of HOXA4 along the aorta and its potential role in human abdominal aortic aneurysms 1 2 2 2 2 3 John H Lillvis , Robert Erdman , Charles M Schworer , Alicia Golden , Kimberly Derr , Zoran Gatalica , 4,5 1,6 7 1 8 1,6 9 Laura A Cox , Jianbin Shen , Richard S Vander Heide , Guy M Lenk , Leigh Hlavaty , Li Li , James R Elmore , 9 9 9 2 1,10 2† David P Franklin , John L Gray , Robert P Garvin , David J Carey , Wayne D Lancaster , Gerard Tromp and Helena Kuivaniemi2*† Abstract Background: The infrarenal abdominal aorta exhibits increased disease susceptibility relative to other aortic regions. Allograft studies exchanging thoracic and abdominal segments showed that regional susceptibility is maintained regardless of location, suggesting substantial roles for embryological origin, tissue composition and site-specific gene expression. Results: We analyzed gene expression with microarrays in baboon aortas, and found that members of the HOX gene family exhibited spatial expression differences. HOXA4 was chosen for further study, since it had decreased expression in the abdominal compared to the thoracic aorta. Western blot analysis from 24 human aortas demonstrated significantly higher HOXA4 protein levels in thoracic compared to abdominal tissues (P 0.001). Immunohistochemical staining for HOXA4 showed nuclear and p