resistin is associated with mortality in patients with traumatic brain injury抵抗素与创伤性脑损伤患者的死亡率.pdfVIP

Dong et al. Critical Care 2010, 14:R190 /content/14/5/R190 RESEARCH Open Access Resistin is associated with mortality in patients with traumatic brain injury 1* 2 2 2 2 2 Xiao-Qiao Dong , Song-Bin Yang , Fang-Long Zhu , Qing-Wei Lv , Guo-Hai Zhang , Hang-Bin Huang Abstract Introduction: Recently, we reported that high levels of resistin are present in the peripheral blood of patients with intracerebral hemorrhage and are associated with a poor outcome. However, not much is known regarding the change in plasma resistin and its relation with mortality after traumatic brain injury (TBI). Thus, we sought to investigate change in plasma resistin level after TBI and to evaluate its relation with disease outcome. Methods: Fifty healthy controls and 94 patients with acute severe TBI were included. Plasma samples were obtained on admission and at days 1, 2, 3, 5 and 7 after TBI. Its concentration was measured by enzyme-linked immunosorbent assay. Results: Twenty-six patients (27.7%) died from TBI within 1 month. After TBI, plasma resistin level in patients increased during the 6-hour period immediately after TBI, peaked within 24 hours, plateaued at day 2, decreased gradually thereafter and was substantially higher than that in healthy controls during the 7-day period. A forward stepwise logistic regression selected plasma resistin level (odds ratio, 1.107; 95% confidence interval, 1.014-1.208; P = 0.023) as an independent predictor for 1-month mortality of patients. A multivariate linear regression showed that plasma resistin level was negatively associated with Glasgow Coma Scale score (t = -6.567, P 0.001). A receiver operating characteristic curve identified plasma resistin cutoff level