response inhibition impairment in high functioning autism and attention deficit hyperactivity disorder evidence from near-infrared spectroscopy data反应抑制损伤的高功能自闭症和注意缺陷多动障碍从近红外光谱数据的证据.pdfVIP

Response Inhibition Impairment in High Functioning Autism and Attention Deficit Hyperactivity Disorder: Evidence from Near-Infrared Spectroscopy Data 1 1 1 2 2 1 1 Ting Xiao , Zhou Xiao , Xiaoyan Ke *, Shanshan Hong , Hongyu Yang , Yanli Su , Kangkang Chu , 1 1 3 Xiang Xiao , Jiying Shen , Yijun Liu 1 Child Mental Health Research Center, Nanjing Brain Hospital affiliated of Nanjing Medical University, Nanjing, Jiangsu, China, 2 Key Laboratory of Child Development and Learning Science, Southeast University, Nanjing, Jiangsu, China, 3 Department of Psychiatry and McKnight Brain Institute, University of Florida, Gainesville, Florida, United States of America Abstract Background: Response inhibition, an important domain of executive function (EF), involves the ability to suppress irrelevant or interfering information and impulses. Previous studies have shown impairment of response inhibition in high functioning autism (HFA) and attention deficit hyperactivity disorder (ADHD), but more recent findings have been inconsistent. To date, almost no studies have been conducted using functional imaging techniques to directly compare inhibitory control between children with HFA and those with ADHD. Method: Nineteen children with HFA, 16 age- and intelligence quotient (IQ)-matched children with ADHD, and 16 typically developing (TD) children were imaged using functional near-infrared spectroscopy (NIRS) while performing Go/No-go and Stroop tasks. Results: Compared with the TD group, children in both the HFA and ADHD groups took more time to respond during the No-go blocks, with reaction time longest for HFA and shortest for TD. Children in the HFA and ADHD groups also made