response to genomic selection the bulmer effect and the potential of genomic selection when the number of phenotypic records is limiting回应基因组选择bulmer效应和潜在的基因选择当表型记录的数量限制.pdfVIP

Van Grevenhof et al. Genetics Selection Evolution 2012, 44:26 Ge n e t i c s /content/44/1/26 Se l e c t i o n Evolution RESEARCH Open Access Response to genomic selection: The Bulmer effect and the potential of genomic selection when the number of phenotypic records is limiting * Elizabeth M Van Grevenhof, Johan AM Van Arendonk and Piter Bijma Abstract Background: Over the last ten years, genomic selection has developed enormously. Simulations and results on real data suggest that breeding values can be predicted with high accuracy using genetic markers alone. However, to reach high accuracies, large reference populations are needed. In many livestock populations or even species, such populations cannot be established when traits are difficult or expensive to record, or when the population size is small. The value of genomic selection is then questionable. Methods: In this study, we compare traditional breeding schemes based on own performance or progeny information to genomic selection schemes, for which the number of phenotypic records is limiting. Deterministic simulations were performed using selection index theory. Our focus was on the equilibrium response obtained after a few generations of selection. Therefore, we first investigated the magnitude of the Bulmer effect with genomic selection. Results: Results showed that the reduction in response due to the Bulmer effect is the same for genomic selection as for selection based on traditional BLUP estimat