原创力文档response surface modeling and optimization of accelerated solvent extraction of four lignans from fructus schisandrae响应面建模和优化的四个木酚素加速溶剂萃取五味子.pdfVIP
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response surface modeling and optimization of accelerated solvent extraction of four lignans from fructus schisandrae响应面建模和优化的四个木酚素加速溶剂萃取五味子
Molecules 2012, 17, 3618-3629; doi:10.3390/molecule
OPEN ACCESS
molecules
ISSN 1420-3049
/journal/molecules
Article
Response Surface Modeling and Optimization of Accelerated
Solvent Extraction of Four Lignans from Fructus Schisandrae
Li-Chun Zhao 1,2, Ying He 1, Xin Deng 1, Geng-Liang Yang 2, Wei Li 3, Jian Liang 1,*
and Qian-Li Tang 4,*
1 Affiliated Ruikang Hospital of Guangxi University of Chinese Medicine, Nanning 530011, China
2 College of Pharmacy, Hebei University, Baoding 071002, China
3 College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China
4 Department of Scientific Research, Guangxi University of Chinese Medicine, Nanning 530011, China
* Authors to whom correspondence should be addressed; E-Mails: ljruikang@126.com (J.L.);
htmgx@163.com (Q.-L.T.); Tel.: +86-771-218-8589 (J.L.); Fax: +86-771-233-5098(J.L.).
Received: 6 February 2012; in revised form: 6 March 2012 / Accepted: 15 March 2012 /
Published: 23 March 2012
Abstract: A new method based on accelerated solvent extraction (ASE) combined with
response surface methodology (RSM) modeling and optimization has been developed for
the extraction of four lignans in Fructus Schisandrae (the fruits of Schisandra chinensis
Baill). The RSM method, based on a three level and three variable Box-Behnken design
(BBD), was employed to obtain the optimal combination of extraction condition. In brief,
the lignans schizandrin, schisandrol B, deoxyschizandrin and schisandrin B were optimally
extracted
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