retinoid x receptor and peroxisome proliferator-activated receptor-gamma agonists cooperate to inhibit matrix metalloproteinase gene expression类维生素a x受体和过氧物酶体proliferator-activated receptor-gamma受体激动剂配合抑制基质金属蛋白酶基因的表达.pdfVIP

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retinoid x receptor and peroxisome proliferator-activated receptor-gamma agonists cooperate to inhibit matrix metalloproteinase gene expression类维生素a x受体和过氧物酶体proliferator-activated receptor-gamma受体激动剂配合抑制基质金属蛋白酶基因的表达.pdf

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retinoid x receptor and peroxisome proliferator-activated receptor-gamma agonists cooperate to inhibit matrix metalloproteinase gene expression类维生素a x受体和过氧物酶体proliferator-activated receptor-gamma受体激动剂配合抑制基质金属蛋白酶基因的表达

Available online /content/10/6/R139 Vol 10 No 6 Open Access Research article Retinoid X receptor and peroxisome proliferator-activated receptor-gamma agonists cooperate to inhibit matrix metalloproteinase gene expression 1 1 1 2 Peter S Burrage *, Adam C Schmucker *, Yanqing Ren , Michael B Sporn and Constance E Brinckerhoff1,3 1Department of Biochemistry, Dartmouth Medical School, North College Street, 7200 Vail Building, Hanover, NH 03755, USA 2Department of Pharmacology, Dartmouth Medical School, North College Street, 7650 Remsen Hall, Hanover, NH 03755, USA 3Department of Medicine, Dartmouth Medical School, 1 Medical Center Drive, Lebanon NH 03756, USA * Contributed equally Corresponding author: Constance E Brinckerhoff, brinckerhoff@ Received: 8 Sep 2008 Revisions requested: 9 Oct 2008 Revisions received: 6 Nov 2008 Accepted: 1 Dec 2008 Published: 1 Dec 2008 Arthritis Research Therapy 2008, 10:R139 (doi:10.1186/ar2564) This article is online at: /content/10/6/R139 © 2008 Burrage et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction We recently described the ability of retinoid X Results Rosiglitazone inhibited MMP-1 and MMP-13 receptor (RXR) ligand LG100268 (LG268) to inhibit interleukin- expression in IL-1--treated SW-1353 cells at the mRNA and 1-beta (IL-1-)-driven matrix metalloproteinase-1 (MMP-1) and