revealing the molecular signatures of host-pathogen interactions暴露的宿主-病原体相互作用的分子签名.pdfVIP

Khor and Hibberd Genome Biology 2011, 12:229 /2011/12/10/229 RE VIE W Revealing the molecular signatures of host-pathogen interactions 1,2,3 1,4 Chiea-Chuen Khor and Martin L Hibberd * On the basis of data obtained using biological candidate Abstract approaches, it has been assumed that broad-based Advances in sequencing technology and genome- responses mediated by B and T cells (both CD4+ and wide association studies are now revealing the + CD8 ) were the primary defenses against infectious agents complex interactions between hosts and pathogen and that these were sufficient for protection against most through genomic variation signatures, which arise from infecting pathogens [3]. Defects in Interleukin 2 (IL-2) evolutionary co-existence. signaling resulted in failed clonal expansion of both B and T cells, leading to severe combined immune defici- ency [3]. Other examples include X-linked agamma- Infectious agents have a long history of causing disease in globulinemia - caused by mutations in Bruton’s tyrosine humans and are a major contributor of childhood mortality kinase - where no mature antibody-producing B cells are worldwide (Table  1). For many infectious agents, a produced, resulting in no an