review of the use of topiramate for treatment of psychiatric disorders审查的使用托吡酯治疗精神疾病.pdfVIP

Annals of General Psychiatry BioMed Central Review Open Access Review of the use of Topiramate for treatment of psychiatric disorders Danilo Arnone* Address: Department of Psychiatry, Springfield University Hospital, St Georges Medical School, London, UK Email: Danilo Arnone* - Danilo.Arnone@swlstg-tr.nhs.uk * Corresponding author Published: 16 February 2005 Received: 12 October 2004 Accepted: 16 February 2005 Annals of General Psychiatry 2005, 4:5 doi:10.1186/1744-859X-4-5 This article is available from: /content/4/1/5 © 2005 Arnone; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. topiramatemood stabiliserspsychotropic medicationspsychiatric disorders. Abstract Background: Topiramate is a new antiepileptic drug, originally designed as an oral hypoglycaemic subsequently approved as anticonvulsant. It has increasingly been used in the treatment of numerous psychiatric conditions and it has also been associated with weight loss potentially relevant in reversing weight gain induced by psychotropic medications. This article reviews pharmacokinetic and pharmacodynamic profile of topiramate, its biological putative role in treating psychiatric disorders and its relevance in clinical practic