rheumatoid peripheral blood phagocytes are primed for activation but have impaired fc-mediated generation of reactive oxygen species风湿性外周血白细胞激活,但正确的受损fc-mediated活性氧的生成.pdfVIP

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rheumatoid peripheral blood phagocytes are primed for activation but have impaired fc-mediated generation of reactive oxygen species风湿性外周血白细胞激活,但正确的受损fc-mediated活性氧的生成.pdf

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rheumatoid peripheral blood phagocytes are primed for activation but have impaired fc-mediated generation of reactive oxygen species风湿性外周血白细胞激活,但正确的受损fc-mediated活性氧的生成

Available online /content/9/2/R29 Vol 9 No 2 Open Access Research article Rheumatoid peripheral blood phagocytes are primed for activation but have impaired Fc-mediated generation of reactive oxygen species 1 2 3 1 Anna-Marie Fairhurst , Paul K Wallace , Ali SM Jawad and Nicolas J Goulding 1William Harvey Research Institute, Barts and the London, Queen Marys School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK 2Flow Cytometry Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA 3Department of Rheumatology, Barts and the London NHS Trust, Bancroft Road, Mile End, London E1 4DG, UK Corresponding author: Nicolas J Goulding, n.j.goulding@qmul.ac.uk Received: 11 Dec 2006 Revisions requested: 22 Jan 2007 Revisions received: 15 Feb 2007 Accepted: 13 Mar 2007 Published: 13 Mar 2007 Arthritis Research Therapy 2007, 9:R29 (doi:10.1186/ar2144) This article is online at: /content/9/2/R29 © 2007 Fairhurst et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Significant levels of circulating immune complexes (ICs) linking of FcγRIIa and FcγRIIIb on neutrophils resulted in a containing rheumatoid factors and immunoglobulin G in significantly decreased production of ROS by RA cells peripheral blood are a characteristic feature of rheumatoid