risk factors of coxiella burnetii (q fever) seropositivity in veterinary medicine students伯纳特氏立克次氏体的风险因素(q热病)血清阳性在兽医的学生.pdfVIP

Risk Factors of Coxiella burnetii (Q Fever) Seropositivity in Veterinary Medicine Students 1 2 2,3 3 4 Myrna M. T. de Rooij , Barbara Schimmer , Bart Versteeg , Peter Schneeberger , Boyd R. Berends , 1 2 1 Dick Heederik , Wim van der Hoek , Inge M. Wouters * 1 Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht, the Netherlands, 2 Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands, 3 Department of Medical Microbiology and Infection Control, Jeroen Bosch Hospital, ‘s-Hertogenbosch, the Netherlands, 4 Division of Veterinary Public Health, Institute for Risk Assessment Sciences, Utrecht, the Netherlands Abstract Background: Q fever is an occupational risk for veterinarians, however little is known about the risk for veterinary medicine students. This study aimed to assess the seroprevalence of Coxiella burnetii among veterinary medicine students and to identify associated risk factors. Methods: A cross-sectional study with questionnaire and blood sample collection was performed among all veterinary medicine students studying in the Netherlands in 2006. Serum samples (n = 674), representative of all study years and study directions, were analyzed for C. burnetii IgG and IgM phase I and II antibodies with an immunofluorescence assay (IFA). Seropositivity was defined as IgG phase I and/or II titer of 1:32 and above. Results: Of the veterinary medicine students 126 (18.7%) had IgG antibodies against C. burnetii. Seropositivity associated risk factors identified were the study direction ‘farm an