原创力文档restructuring of pancreatic islets and insulin secretion in a postnatal critical window重组产后胰岛细胞和胰岛素分泌的重要窗口.pdfVIP
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restructuring of pancreatic islets and insulin secretion in a postnatal critical window重组产后胰岛细胞和胰岛素分泌的重要窗口
Restructuring of Pancreatic Islets and Insulin Secretion in
a Postnatal Critical Window
1 1 3 ´ 2 1
Cristina Aguayo-Mazzucato , Carmen Sanchez-Soto , Victoria Godinez-Puig , Gabriel Gutierrez-Ospina , Marcia Hiriart *
´
1 Department of Biophysics, Institute of Cellular Physiology, National Autonomous University of Mexico, Mexico City, Mexico, 2 Department of Cell
´
Biology and Physiology, Biomedical Research Institute, National Autonomous University of Mexico, Mexico City, Mexico, 3 Faculty of Medicine,
National Autonomous University of Mexico, Mexico City, Mexico
Function and structure of adult pancreatic islets are determined by early postnatal development, which in rats corresponds to
the first month of life. We analyzed changes in blood glucose and hormones during this stage and their association with
morphological and functional changes of alpha and beta cell populations during this period. At day 20 (d20), insulin and
glucose plasma levels were two- and six-fold higher, respectively, as compared to d6. Interestingly, this period is characterized
by physiological hyperglycemia and hyperinsulinemia, where peripheral insulin resistance and a high plasmatic concentration
of glucagon are also observed. These functional changes were paralleled by reorganization of islet structure, cell mass and
aggregate size of alpha and beta cells. Cultured beta cells from d20 secreted the same amount of insulin in 15.6 mM than in
5.6 mM glucose (basal conditions), and were characterized by a high basal insulin secretion. However, beta cells from d28 were
alr
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