原创力文档repeated episodes of heroin cause enduring alterations of circadian activity in protracted abstinence反复发作的海洛因导致长期禁欲持久改变的生理活动.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
repeated episodes of heroin cause enduring alterations of circadian activity in protracted abstinence反复发作的海洛因导致长期禁欲持久改变的生理活动
Brain Sci. 2012, 2, 421-433; doi:10.3390/brainsci2030421
OPEN ACCESS
brain sciences
ISSN 2076-3425
/journal/brainsci/
Article
Repeated Episodes of Heroin Cause Enduring Alterations of
Circadian Activity in Protracted Abstinence
Luis Stinus 1,2, Martine Cador 1,2 and Stephanie Caille 1,2,*
1 University of Bordeaux, INCIA, F-33076 Bordeaux, France;
E-Mails: luis.stinus.saez@ (L.S.); martine.cador@u-bordeaux2.fr (M.C.)
2 National Center of Scientific Research (CNRS), UMR 5287, INCIA, F-33076 Bordeaux, France
* Author to whom correspondence should be addressed; E-Mail: stephanie.garnier@u-bordeaux2.fr;
Tel.: +33-557-57-1563; Fax: +33-556-90-0278.
Received: 31 July 2012; in revised form: 4 September 2012 / Accepted: 11 September 2012 /
Published: 20 September 2012
Abstract: Opiate withdrawal is followed by a protracted abstinence syndrome consisting
of craving and physiological changes. However, few studies have been dedicated to both
the characterization and understanding of these long-term alterations in post-dependent
subjects. The aim of the present study was to develop an opiate dependence model, which
induces long-lasting behavioral changes in abstinent rats. Here, we first compared the
effects of several protocols for the induction of opiate dependence (morphine pellets,
repeated morphine or heroin injections) on the subsequent response to heroin challenges
(0.25 mg/kg) at different time points during abstinence (3, 6, 9 and 18 weeks). In a second
set
您可能关注的文档
- regulatory variation at glypican-3 underlies a major growth qtl in mice监管变化glypican-3构成一个主要增长qtl老鼠.pdf
- regulatory t cells in arterivirus and coronavirus infections do they protect against disease or enhance it调节性t细胞在arterivirus和冠状病毒感染他们预防疾病或增强.pdf
- rehabilitating information恢复信息.pdf
- regulatory t cells in systemic lupus erythematosus past, present and future调节性t细胞在系统性红斑狼疮的过去、现在和未来.pdf
- regulatory t cells suppress t cell activation at the pathologic site of human visceral leishmaniasis调节性t细胞抑制t细胞激活人类内脏利什曼病的病理部位.pdf
- reinventing diagnostics for personalized therapy in oncology重塑诊断肿瘤的个性化治疗.pdf
- reinforcement of gametic isolation in drosophila强化果蝇的配子隔离.pdf
- regulatory t cells suppress natural killer cells during plasmid dna vaccination in mice, blunting the cd8+ t cell immune response by the cytokine tgfβ调节性t细胞抑制自然杀伤细胞在质粒dna疫苗在小鼠体内,削弱cd8 + t细胞免疫反应的细胞因子tgfβ.pdf
- regulatory interdependence of myeloid transcription factors revealed by matrix rnai analysis矩阵rnai所暴露出的监管相互依存的骨髓转录因子分析.pdf
- rejection of unfair offers can be driven by negative emotions, evidence from modified ultimatum games with anonymity拒绝不公平的提供可以被负面情绪驱动的,证据与匿名修改最后通牒游戏.pdf
- repeated parallel evolution of parental care strategies within xenotilapia, a genus of cichlid fishes from lake tanganyika重复在xenotilapia亲代抚育的平行进化策略,从坦噶尼喀湖的丽鱼科鱼属鱼类.pdf
- repeated small perturbation approach reveals transcriptomic steady states重复小扰动方法揭示转录组稳定状态.pdf
- repeated post-exercise administration with a mixture of leucine and glucose alters the plasma amino acid profile in standardbred trotters重复运动后政府的亮氨酸和葡萄糖改变等离子体氨基酸在标准竞赛用马玩耍.pdf
- repeated training with augmentative vibrotactile feedback increases object manipulation performance反复训练和扩大的vibrotactile反馈增加对象操纵性能.pdf
- reperfusion does not improve impaired rapid-onset cortical plasticity in patients with severe stenosis of the internal carotid artery再灌注不改善受损急性皮层可塑性在颈内动脉严重狭窄患者.pdf
- repeated allergen exposure reduce early phase airway response and leukotriene release despite upregulation of 5-lipoxygenase pathways反复过敏原接触减少早期气道反应和白三烯释放尽管upregulation 5-lipoxygenase通路.pdf
- repercussions of mild diabetes on pregnancy in wistar rats and on the fetal development轻度糖尿病对妊娠的影响wistar鼠和胎儿发育.pdf
- repeat length and rna expression level are not primary determinants in cug expansion toxicity in drosophila models重复长度和rna表达水平也不主要决定因素cug扩张毒性在果蝇模型.pdf
- repeated-batch ethanol production from sweet sorghum juice by saccharomyces cerevisiae immobilized on sweet sorghum stalksrepeated-batch从甜高粱乙醇生产酿酒酵母固定化对甜高粱秸秆汁.pdf
- repetition priming affects guessing not familiarity重复启动影响猜测不熟悉.pdf
文档评论（0）