原创力文档repeated small perturbation approach reveals transcriptomic steady states重复小扰动方法揭示转录组稳定状态.pdfVIP
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repeated small perturbation approach reveals transcriptomic steady states重复小扰动方法揭示转录组稳定状态
Repeated Small Perturbation Approach Reveals
Transcriptomic Steady States
1. 2. 3 1 1
Ching-Lung Huang , Wun-Yi Shu , Min-Lung Tsai , Chi-Shiun Chiang , Cheng-Wei Chang , Chiu-Ting
1 1
Chang , Ian C. Hsu *
1 Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, 2 Institute of Statistics, National Tsing Hua
University, Hsinchu, Taiwan, 3 Institute of Athletics, National Taiwan Sport University, Taichung, Taiwan
Abstract
The study of biological systems dynamics requires elucidation of the transitions of steady states. A ‘‘small perturbation’’
approach can provide important information on the ‘‘steady state’’ of a biological system. In our experiments, small
perturbations were generated by applying a series of repeating small doses of ultraviolet radiation to a human keratinocyte
cell line, HaCaT. The biological response was assessed by monitoring the gene expression profiles using cDNA microarrays.
Repeated small doses (10 J/m2) of ultraviolet B (UVB) exposure modulated the expression profiles of two groups of genes in
opposite directions. The genes that were up-regulated have functions mainly associated with anti-proliferation/anti-
mitogenesis/apoptosis, and the genes that were down-regulated were mainly related to proliferation/mitogenesis/anti-
apoptosis. For both groups of genes, repetition of the small doses of UVB caused an immediate response followed by
relaxation between successive small perturbations. This cyclic pattern was suppressed when large doses (233 or 582.5 J/m2)
of UVB were applied. Our method and results contribute to
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