原创力文档regulatory t cells suppress t cell activation at the pathologic site of human visceral leishmaniasis调节性t细胞抑制t细胞激活人类内脏利什曼病的病理部位.pdfVIP
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regulatory t cells suppress t cell activation at the pathologic site of human visceral leishmaniasis调节性t细胞抑制t细胞激活人类内脏利什曼病的病理部位
Regulatory T Cells Suppress T Cell Activation at the
Pathologic Site of Human Visceral Leishmaniasis
1 2 1 3 1
Ambak K. Rai , Chandreshwar P. Thakur , Amar Singh , Tulika Seth , Sandeep K. Srivastava ,
1 1
Pushpendra Singh , Dipendra K. Mitra *
1 Cellular Immunology Division, Department of T.I.I., All India Institute of Medical Sciences (AIIMS), Ansari Nagar, New Delhi, India, 2 Balaji Utthan Sansthan, Patna, Bihar,
India, 3 Department of Hematology, All India Institute of Medical Sciences (AIIMS), Ansari Nagar, New Delhi, India
Abstract
Suppression of T cell response is thought to be involved in the pathogenesis of visceral leishmaniasis (VL). Regulatory T cell
(Treg) mediated immune-suppression is reported in animal models of Leishmania infection. However, their precise role
among human patients still requires pathologic validation. The present study is aimed at understanding the frequency
dynamics and function of Treg cells in the blood and bone marrow (BM) of VL patients. The study included 42
parasitologically confirmed patients, 17 healthy contact and 9 normal bone marrow specimens (NBM). We show i) the
selective accumulation of Treg cells at one of the disease inflicted site(s), the BM, ii) their in vitro expansion in response to LD
antigen and iii) persistence after successful chemotherapy. Results indicate that the Treg cells isolated from BM produces IL-
10 and may inhibit T cell activation in IL-10 dependent manner. Moreover, we observed significantly higher levels of IL-10
among drug unresponsive patients, suggesting their critical role in suppression of immunity among VL patients. Our results
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