reclassification and subtyping of so-called malignant fibrous histiocytoma of bone comparison with cytogenetic features重新分类和子类型化的所谓骨恶性纤维组织细胞瘤与细胞遗传学特征.pdfVIP

Mertens et al. Clinical Sarcoma Research 2011, 1:10 /content/1/1/10 CLINICAL SARCOMA RESEARCH RESEARCH Open Access Reclassification and subtyping of so-called malignant fibrous histiocytoma of bone: comparison with cytogenetic features 1* 2 3 4 5 6 Fredrik Mertens , Salvatore Romeo , Judith VMG Bovée , Roberto Tirabosco , Nick Athanasou , Marco Alberghini , 3 2 7 8 9 1 Pancras CW Hogendoorn , Angelo P Dei Tos , Raf Sciot , Henryk A Domanski , Kristina Åström , Nils Mandahl and Maria Debiec-Rychter10 Abstract Background: The diagnostic entity malignant fibrous histiocytoma (MFH) of bone is, like its soft tissue counterpart, likely to be a misnomer, encompassing a variety of poorly differentiated sarcomas. When reviewing a series of 57 so-called MFH of bone within the framework of the EuroBoNeT consortium according to up-to-date criteria and ancillary immunohistochemistry, a fourth of all tumors were reclassified and subtyped. Methods: In the present study, the cytogenetic data on 11 of these tumors (three myoepithelioma-like sarcomas, two leiomyosarcomas, one undifferentiated pleomorphic sarcoma with incomplete myogenic differentiation, two undifferentiated pleomorphic sarcomas, one osteosarcoma, one spindle cell sarcoma, and one unclassifiable biphasic sarcoma) are presented. Results: All tumors were high-grade lesions and showed very complex karyotypes. Neither the overall pattern (ploidy level, degree of complexity) nor specific cytogenetic features distinguished any of the subtypes. The subgroup of myoepithelioma-li