reperfusion does not improve impaired rapid-onset cortical plasticity in patients with severe stenosis of the internal carotid artery再灌注不改善受损急性皮层可塑性在颈内动脉严重狭窄患者.pdfVIP

Reperfusion Does Not Improve Impaired Rapid-Onset Cortical Plasticity in Patients with Severe Stenosis of the Internal Carotid Artery 1,2,4 2 ¨ 2 3 2 ¨ 1,4,5 Jonathan List , Johannes Albers , Julia Kurten , Arne Schwindt , Eike Wilbers , Agnes Floel * ´ ¨ ¨ ¨ 1 Department of Neurology, Charite - Universitatsmedizin Berlin, Berlin, Germany, 2 Department of Neurology, University Hospital Munster, Munster, Germany, ¨ ¨ ´ ¨ 3 Department of Vascular Surgery, University Hospital Munster, Munster, Germany, 4 Center for Stroke Research Berlin, Charite - Universitatsmedizin Berlin, Berlin, ´ ¨ Germany, 5 Cluster of Excellence NeuroCure, Charite - Universitatsmedizin Berlin, Berlin, Germany Abstract Background: Severe stenosis of the internal carotid artery (ICA) has been associated with impaired cognition in patients, but its effect on rapid-onset cortical plasticity is not known. Carotid endarterectomy (CEA) in patients with severe ICA stenosis reduces stroke risk, but the impact on cognition or physiology of the respective hemisphere remains controversial. Methods/Results: 16 patients with severe stenosis of the ICA and 16 age and sex matched controls were included. Rapid- onset cortical plasticity was assessed using the paired-associative stimulation (PAS) protocol. PAS models long-term synaptic poten