regulatory t cells in systemic lupus erythematosus past, present and future调节性t细胞在系统性红斑狼疮的过去、现在和未来.pdfVIP

Available online /content/10/6/227 Review Regulatory T cells in systemic lupus erythematosus: past, present and future David A Horwitz Division of Rheumatology and Immunology, Department of Medicine, University of Southern California, Keck School of Medicine, 2011 Zonal Avenue, HMR 711, Los Angeles, CA 90033, USA Corresponding author: David A Horwitz, dhorwitz@ Published: 14 November 2008 Arthritis Research Therapy 2008, 10:227 (doi:10.1186/ar2511) This article is online at /content/10/6/227 © 2008 BioMed Central Ltd Abstract antigen-presenting cells. Evidence for each of these mechanisms will be discussed. Regulatory/suppressor T cells (Tregs) maintain immunologic homeo- stasis and prevent autoimmunity. In this article, past studies and recent studies of Tregs in mouse models for lupus and of human T cells with the ability to control autoantibody production systemic lupus erythematosus are reviewed concentrating on were first described by Teague and Friou in 1969. These + + + CD4 CD25 Foxp3 Tregs. These cells consist of thymus-derived, workers reported that the transfer of thymus cells from young natural Tregs and peripherally induced Tregs that are similar mice to old mice prevented the development of anti- phenotypically and functionally. These Tregs are decreased in young lupus-prone mice, but are present in normal numbers in nucleoprotein antibodies, and also blocked their appearance mice with established diseas