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results of noninvasive ventilation in very old patients无创性通风非常古老的患者的结果
Schortgen et al. Annals of Intensive Care 2012, 2:5
/content/2/1/5
RESEARCH Open Access
Results of noninvasive ventilation in very old
patients
1,2* 1 1 1 1
Frederique Schortgen , Arnaud Follin , Lucilla Piccari , Ferran Roche-Campo , Guillaume Carteaux ,
3 3 1 3,4 2,4,5
Elodie Taillandier-Heriche , Sebastien Krypciak , Arnaud W Thille , Elena Paillaud and Laurent Brochard
Abstract
Background: Noninvasive ventilation (NIV) is frequently used for the management of acute respiratory failure (ARF)
in very old patients (≥ 80 years), often in the context of a do-not-intubate order (DNI). We aimed to determine its
efficacy and long-term outcome.
Methods: Prospective cohort of all patients admitted to the medical ICU of a tertiary hospital during a 2-year
period and managed using NIV. Characteristics of patients, context of NIV, and treatment intensity were compared
for very old and younger patients. Six-month survival and functional status were assessed in very old patients.
Results: During the study period, 1,019 patients needed ventilatory support and 376 (37%) received NIV. Among
them, 163 (16%) very old patients received ventilatory support with 60% of them managed using NIV compared
with 32% of younger patients (p 0.0001). Very old patients received NIV more frequently with DNI than in
younger patients (40% vs. 8%). Such cases were associated with high mortality for both very old and younger
patients. Hospital mortality was higher in very old than in younger patients but did not differ when NIV was used
for cardiogenic pulmonary edema or acute-
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