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restriction site tiling analysis accurate discovery and quantitative genotyping of genome-wide polymorphisms using nucleotide arrays限制网站花砖分析准确发现和定量pcr的全基因组核苷酸多态性使用数组
Pespeni et al. Genome Biology 2010, 11:R44
/2010/11/4/R44
M E T H O D Open Access
Method
Restriction Site Tiling Analysis: accurate discovery
and quantitative genotyping of genome-wide
polymorphisms using nucleotide arrays
1 1 1,2 1
Melissa H Pespeni* , Thomas A Oliver , Mollie K Manier and Stephen R Palumbi
typingA method for the simultaneous identificationof polymorphic loci andpresented.Restriction Site Tiling Analysisof thousands of loci in individuals isthe quantitative geno-
Abstract
High-throughput genotype data can be used to identify genes important for local adaptation in wild populations,
phenotypes in lab stocks, or disease-related traits in human medicine. Here we advance microarray-based genotyping
for population genomics with Restriction Site Tiling Analysis. The approach simultaneously discovers polymorphisms
and provides quantitative genotype data at 10,000s of loci. It is highly accurate and free from ascertainment bias. We
apply the approach to uncover genomic differentiation in the purple sea urchin.
Background Atlantic salmon, common frogs, and beech trees [17-21].
Uncovering the genetic underpinnings of adaptive evolu- These methods require little prior marker or sequence
tion is key to understanding the evolutionary processes information. However, they are limited by the number of
that generate biodiversity [1]. The combined use of loci that can be examined (usually hundreds) and the
genome scans and population genetic analyses has been focus on anonymous loci limits identification
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