原创力文档risk-based indicators of canadians exposures to environmental carcinogens风险指标的加拿大人环境致癌物的暴露.pdfVIP
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risk-based indicators of canadians exposures to environmental carcinogens风险指标的加拿大人环境致癌物的暴露
Setton et al. Environmental Health 2013, 12:15
/content/12/1/15
RESEARCH Open Access
Risk-based indicators of Canadians’ exposures to
environmental carcinogens
1* 2 1 1 3 1
Eleanor Setton , Perry Hystad , Karla Poplawski , Roslyn Cheasley , Alejandro Cervantes-Larios , C Peter Keller
and Paul A Demers4
Abstract
Background: Tools for estimating population exposures to environmental carcinogens are required to support
evidence-based policies to reduce chronic exposures and associated cancers. Our objective was to develop
indicators of population exposure to selected environmental carcinogens that can be easily updated over time, and
allow comparisons and prioritization between different carcinogens and exposure pathways.
Methods: We employed a risk assessment-based approach to produce screening-level estimates of lifetime excess
cancer risk for selected substances listed as known carcinogens by the International Agency for Research on Cancer.
Estimates of lifetime average daily intake were calculated using population characteristics combined with
concentrations (circa 2006) in outdoor air, indoor air, dust, drinking water, and food and beverages from existing
monitoring databases or comprehensive literature reviews. Intake estimates were then multiplied by cancer potency
factors from Health Canada, the United States Environmental Protection Agency, and the California Office of
Environmental Health Hazard Assessment to estimate lifetime excess cancer risks associated with each substance
and exposure pathway. Lifetime excess cancer risks in excess of 1 per million people are identified as potential
priorities for further attention.
Results: Based on data representing average con
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