原创力文档rituximab for children with immune thrombocytopenia a systematic review美罗华对儿童免疫血小板减少系统回顾.pdfVIP
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rituximab for children with immune thrombocytopenia a systematic review美罗华对儿童免疫血小板减少系统回顾
Rituximab for Children with Immune Thrombocytopenia:
A Systematic Review
1,2 1 3 1,2 3
Yi Liang , Lingli Zhang *, Ju Gao , Die Hu , Yuan Ai
1 Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, China, 2 West China School of Pharmacy, Sichuan University, Chengdu,
China, 3 Department of Pediatric Hematology and Oncology, West China Second University Hospital, Sichuan University, Chengdu, China
Abstract
Background: Rituximab has been widely used off-label as a second line treatment for children with immune
thrombocytopenia (ITP). However, its role in the management of pediatric ITP requires clarification. To understand and
interpret the available evidence, we conducted a systematic review to assess the efficacy and safety of rituximab for children
with ITP.
Methodology/Principal Findings: We searched MEDLINE, EMBASE, Cochrane Library, CBM, CNKI, abstract databases of
American Society of Hematology, American Society of Clinical Oncology and Pediatric Academic Society. Clinical studies
published in full text or abstract only in any language that met predefined inclusion criteria were eligible. Efficacy analysis
was restricted to studies enrolling 5 or more patients. Safety was evaluated from all studies that reported data of toxicity. 14
studies (323 patients) were included for efficacy assessment in children with primary ITP. The pooled complete response
(platelet count $1006109 9
/L) and response (platelet count $30 610 /L) rate after rituximab treatment were 39% (95% CI,
30% to 49%) and 68% (95%CI, 58% to 77%), respectively, with median response duration of 12
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