robust framework for pet image reconstruction incorporating system and measurement uncertainties健壮的pet图像重建框架整合系统和测量的不确定性.pdfVIP

Robust Framework for PET Image Reconstruction Incorporating System and Measurement Uncertainties 1,2 1 2 1 3 1 2 Huafeng Liu , Song Wang , Fei Gao , Yi Tian , Wufan Chen *, Zhenghui Hu *, Pengcheng Shi 1 State Key Laboratory of Modern Optical Instrumentation, Department of Optical Engineering, Zhejiang University, Hangzhou, China, 2 B. Thomas Golisano College of Computing and Information Sciences, Rochester Institute of Technology, Rochester, United States of America, 3 School of Biomedical Engineering, Southern Medical University, Guangzhou, China Abstract In Positron Emission Tomography (PET), an optimal estimate of the radioactivity concentration is obtained from the measured emission data under certain criteria. So far, all the well-known statistical reconstruction algorithms require exactly known system probability matrix a priori, and the quality of such system model largely determines the quality of the reconstructed images. In this paper, we propose an algorithm for PET image reconstruction for the real world case where the PET system model is subject to uncertainties. The method counts PET reconstruction as a regularization problem and the image estimation is achieved by means of an uncertainty weighted least squares framework. The performance of our work is evaluated with the Shepp-Logan simulated and real phantom data, which demonstrates significant improvements in image quality over the least squares reconstruction efforts. Citation: Liu H, Wang S, Gao F, Tian Y, Chen W, et al. (2012) Robust Framework for PET Image Reconstruction Incorporating System and Measurement Uncertainties. PLoS ONE 7(3): e32224. doi:10.1371/journal.pone.0032224 Editor: Kewei Chen, Banne