review of alzheimers disease scales is there a need for a new multi-domain scale for therapy evaluation in medical practice对阿尔茨海默病量表有需要医疗实践的新疗法多域量表评估.pdfVIP

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review of alzheimers disease scales is there a need for a new multi-domain scale for therapy evaluation in medical practice对阿尔茨海默病量表有需要医疗实践的新疗法多域量表评估.pdf

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review of alzheimers disease scales is there a need for a new multi-domain scale for therapy evaluation in medical practice对阿尔茨海默病量表有需要医疗实践的新疗法多域量表评估

Robert et al. Alzheimer ’s Research Therapy 2010, 2:24 /content/2/4/24 RESEARCH Open Access Review of Alzheimer’s disease scales: is there a need for a new multi-domain scale for therapy evaluation in medical practice? 1* 2 3 4 5 6 Philippe Robert , Steven Ferris , Serge Gauthier , Ralf Ihl , Bengt Winblad , Frank Tennigkeit Abstract Introduction: The present review of Alzheimer’s disease (AD) rating scales aims to outline the need for a new rating scale to be used in routine clinical practice for long-term medical care of AD patients. An ideal scale would be: 1) practical, easy and quick to administer for an experienced clinician; 2) validated for AD; 3) multi-domain: covering the AD-relevant areas of cognition, activities of daily living, behavior, communication/social interaction, and quality of life; 4) applicable to all AD severity stages; 5) able to monitor disease progression; and 6) sensitive to measure therapy effects. Methods: The National Library of Medicines’ MEDLINE database was searched for the years 1981 to September 2008, using a set of keywords aiming to select instruments which cover at least some of the requirements for an ideal practical AD scale for therapy evaluation. Measures for AD staging and screening tests were not considered for review. Results: Of 1,902 articles resulting from the literature search, 68 relevant AD scales were identified. Most of them were scales that predominantly measure the severity of major dysfunctions in particular AD domains. Only five scales met some of the requirements for a practical multi-domain AD scale, but did not possess all required characteristics. Conclusions: Despite the multitude of AD scales for various purposes, there remains a