role of amia in the morphological transition of helicobacter pylori and in immune escape角色amia形态过渡的幽门螺杆菌和免疫逃逸.pdfVIP

Role of AmiA in the Morphological Transition of Helicobacter pylori and in Immune Escape 1 1 ` 2 3 4 ´ 2 Catherine Chaput , Chantal Ecobichon , Nadege Cayet , Stephen E. Girardin , Catherine Werts , Stephanie Guadagnini , ´ 2 5 ` 1 1* Marie-Christine Prevost , Dominique Mengin-Lecreulx , Agnes Labigne , Ivo G. Boneca ´ ´ ´ ´ 1 Unite de Pathogenie Bacterienne des Muqueuses, Institut Pasteur, Paris, France, 2 Plate-Forme de Microscopie Electronique, Institut Pasteur, Paris, France, 3 Groupe ´ ´ ´ ´ ´ Avenir, INSERM U389, Unite de Pathogenie Microbienne Moleculaire, Institut Pasteur, Paris, France, 4 Groupe Immunite Innee et Signalisation, Institut Pasteur, Paris, ´ ´ France, 5 Enveloppes Bacteriennes et Antibiotiques, UMR 8619 CNRS, Universite Paris-Sud, Orsay, France The human gastric pathogen Helicobacter pylori is responsible for peptic ulcers and neoplasia. Both in vitro and in the human stomach it can be found in two forms, the bacillary and coccoid forms. The molecular mechanisms of the morphological transition between these two forms and the role of coccoids remain largely unknown. The peptidoglycan (PG) layer is a major determinant of bacterial cell shape, and therefore we studied H. py