review and classification of variability analysis techniques with clinical applications审查和分类的可变性分析技术与临床应用.pdfVIP

Bravi et al. BioMedical Engineering OnLine 2011, 10:90 /content/10/1/90 REVIEW Open Access Review and classification of variability analysis techniques with clinical applications Andrea Bravi1*, André Longtin2 and Andrew JE Seely1,3,4 * Correspondence: a. Abstract bravi@uottawa.ca 1Department of Cellular and Analysis of patterns of variation of time-series, termed variability analysis, represents a Molecular Medicine, University of rapidly evolving discipline with increasing applications in different fields of science. In Ottawa, Ottawa, Ontario, Canada Full list of author information is medicine and in particular critical care, efforts have focussed on evaluating the clinical available at the end of the article utility of variability. However, the growth and complexity of techniques applicable to this field have made interpretation and understanding of variability more challenging. Our objective is to provide an updated review of variability analysis techniques suitable for clinical applications. We review more than 70 variability techniques, providing for each technique a brief description of the underlying theory and assumptions, together with a summary of clinical applications. We propose a revised classification for the domains of variability techniques, which include statistical, geometric, energetic, informational, and invariant. We discuss the process of calculation, often necessitating a mathematical transform of the time-series. Our aims