原创力文档rule based classifier for the analysis of gene-gene and gene-environment interactions in genetic association studies基于规则的分类器为分析基因基因和基因-环境相互作用的遗传关联研究.pdfVIP
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rule based classifier for the analysis of gene-gene and gene-environment interactions in genetic association studies基于规则的分类器为分析基因基因和基因-环境相互作用的遗传关联研究
Lehr et al. BioData Mining 2011, 4:4
/content/4/1/4 BioData Mining
RESEARCH Open Access
Rule based classifier for the analysis of gene-gene
and gene-environment interactions in genetic
association studies
1,2* 2 1 2,3 4
Thorsten Lehr , Jing Yuan , Dirk Zeumer , Supriya Jayadev , Marylyn D Ritchie
* Correspondence: thorsten. Abstract
lehr@
1Boehringer Ingelheim Pharma Background: Several methods have been presented for the analysis of complex
GmbH Co. KG, Department of
Drug Metabolism and interactions between genetic polymorphisms and/or environmental factors. Despite
Pharmacokinetics, 88397 Biberach the available methods, there is still a need for alternative methods, because no single
an der Riss, Germany method will perform well in all scenarios. The aim of this work was to evaluate the
Full list of author information is
available at the end of the article performance of three selected rule based classifier algorithms, RIPPER, RIDOR and
PART, for the analysis of genetic association studies.
Methods: Overall, 42 datasets were simulated with three different case-control
models, a varying number of subjects (300, 600), SNPs (500, 1500, 3000) and noise
(5%, 10%, 20%). The algorithms were applied to each of the datasets with a set of
algorithm-specific settings. Results were further investigated with respect to a) the
Model, b) the Rules, and c) the Attribute level. Data analysi
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