saccharomyces boulardii improves intestinal epithelial cell restitution by inhibiting αvβ5 integrin activation state酿酒boulardii改善肠道上皮细胞恢复通过抑制αvβ5整合素激活状态.pdfVIP

Saccharomyces boulardii Improves Intestinal Epithelial Cell Restitution by Inhibiting avb5 Integrin Activation State 1,2. 1,2. 1,2 ´ 1,2 3 Alexandra Canonici , Emilie Pellegrino , Carole Siret , Chloe Terciolo , Dorota Czerucka , 1,2 1,2 1,2 ´ 1,2 ´ ´ ´ 1,2 Sonia Bastonero , Jacques Marvaldi , Dominique Lombardo , Veronique Rigot , Frederic Andre * ´ 1 Aix-Marseille Universite, Centre de Recherche en Oncologie et Oncopharmacologie, Marseille, France, 2 Inserm UMR 9111, Marseille, France, 3 Team 4, Inflammation, ´ ´ ´ ´ Cancer, Cancer Stem Cells, INSERM U895, Centre Mediterraneen de Medecine Moleculaire, Nice, France Abstract Intestinal epithelial cell damage is frequently seen in the mucosal lesions of infectious or inflammatory bowel diseases such as ulcerative colitis or Crohn’s disease. Complete remission of these diseases requires both the disappearance of inflammation and the repair of damaged epithelium. Saccharomyces boulardii (Sb, Biocodex) is a non-pathogenic yeast widely used as a preventive and therapeutic probiotic for the prevention and treatment of diarrhea and other gastrointestinal disorders. We recently showed that it enhances the repair of intestinal epithelium through activation of a2b1 integrin collagen receptors. In the present study, w