safety and efficacy of methylene blue combined with artesunate or amodiaquine for uncomplicated falciparum malaria a randomized controlled trial from burkina faso安全性和有效性的亚甲蓝结合青蒿琥酯或阿莫地喹无并发症恶性疟疾来自布基纳法索的随机对照试验.pdfVIP
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safety and efficacy of methylene blue combined with artesunate or amodiaquine for uncomplicated falciparum malaria a randomized controlled trial from burkina faso安全性和有效性的亚甲蓝结合青蒿琥酯或阿莫地喹无并发症恶性疟疾来自布基纳法索的随机对照试验
Safety and Efficacy of Methylene Blue Combined with
Artesunate or Amodiaquine for Uncomplicated
Falciparum Malaria: A Randomized Controlled Trial from
Burkina Faso
1 1 ´ 1 2 3
Augustin Zoungrana , Boubacar Coulibaly , Ali Sie , Ingeborg Walter-Sack , Frank P. Mockenhaupt ,
´ 1 4 5 6 7 ¨ 7
Bocar Kouyate , R. Heiner Schirmer , Christina Klose , Ulrich Mansmann , Peter Meissner , Olaf Muller *
´
1 Centre de Recherche en Sante de Nouna, Nouna, Burkina Faso, 2 Department of Internal Medicine VI, Clinical Pharmacology and Pharmaco-epidemiology, Medical
´
School, Ruprecht-Karls-University, Heidelberg, Germany, 3 Institute of Tropical Medicine and International Health, Charite – University Medicine Berlin, Berlin, Germany,
4 Biochemistry Centre, Ruprecht-Karls-University, Heidelberg, Germany, 5 Institute of Medical Biometrics and Informatics, Ruprecht-Karls-University, Heidelberg, Germany,
¨
6 Institute of Bioinformatics and Epidemiology, Medical School, Ludwig Maximilians University Munchen, Germany, 7 Department of Tropical Hygiene and Public Health,
Medical School, Ruprecht-Karls-University, Heidelberg, Germany
Abstract
Background: Besides existing artemisinin-based combination therapies, alternative safe, effective and affordable drug
combinations against falciparum malaria are needed. Methylene blue (MB) was the first synthetic antima
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