原创力文档risk of end-stage renal disease associated with gout a nationwide population study终末期肾病的风险与痛风全国人口研究.pdfVIP
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risk of end-stage renal disease associated with gout a nationwide population study终末期肾病的风险与痛风全国人口研究
Yu et al. Arthritis Research Therapy 2012, 14:R83
/content/14/2/R83
RESEARCH ARTICLE Open Access
Risk of end-stage renal disease associated with
gout: a nationwide population study
1,2 1,3* 1,2 4,5 6 1
Kuang-Hui Yu , Chang-Fu Kuo , Shue-Fen Luo , Lai-Chu See , I-Jun Chou , Hsiao-Chun Chang and
Meng-Jiun Chiou4,5
Abstract
Introduction: We explored the risk of end-stage renal disease (ESRD) among gout patients in a representative
cohort in Taiwan.
Methods: The primary database used was the Taiwan National Health Insurance Research Database. Subjects older
than 20 years without ESRD, coronary heart disease, or stroke were included in the study. The case definition of
gout in the present study was gout diagnosis and medical treatment for gout. An ESRD case was defined by the
presence of chronic renal failure necessitating long-term renal replacement therapy. Multivariate Cox proportional
hazards models were used to evaluate the risk of ESRD among gout patients.
Results: The analysis included data of 656,108 patients who were followed up for a mean of 8.0 years. Among
them, 19,963 (3.0%) patients had gout. At the end of 2008, 2,377 individuals (gout, n = 276; non-gout, n = 2,101)
had ESRD, and 861 individuals (gout, n = 77, 27.9%; non-gout, n = 521, 24.8%) died due to ESRD. The rates of
incidence of ESRD were 1.73 and 0.41 cases per 1,000 patient-years in the gout and non-gout groups. After
adjustment for age, sex, and history of diabetes mellitus and/or hypertension, gout was associated with a hazard
ratio (HR) of 1.57 for ESRD (95% confidence interval [CI], 1.38-1.79; P 0.001). In patients with ESRD, the adjusted
HR for death in patients with gout was 0.95 (0.74-1.23, P = 0.7
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