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sample size requirements to detect the effect of a group of genetic variants in case-control studies样本量要求检测一组遗传变异的影响的病例对照研究.pdf

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sample size requirements to detect the effect of a group of genetic variants in case-control studies样本量要求检测一组遗传变异的影响的病例对照研究

Emerging Themes in Epidemiology BioMed Central Analytic perspective Open Access Sample size requirements to detect the effect of a group of genetic variants in case-control studies 1 2 2 Ramal Moonesinghe* , Quanhe Yang and Muin J Khoury Address: 1Office of Minority Health and Health Disparities, Centers for Disease Control and Prevention, Atlanta, Georgia, USA and 2National Office of Public Health Genomics, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA Email: Ramal Moonesinghe* - RMoonesinghe@; Quanhe Yang - QYang@; Muin J Khoury - MKhoury@ * Corresponding author Published: 3 December 2008 Received: 28 September 2007 Accepted: 3 December 2008 Emerging Themes in Epidemiology 2008, 5:24 doi:10.1186/1742-7622-5-24 This article is available from: /content/5/1/24 © 2008 Moonesinghe et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Because common diseases are caused by complex interactions among many genetic variants along with environmental risk factors, very large sample sizes are usually needed to detect such effects in case-control studies. Nevertheless, many genetic variants act in well defined biologic sy